5 Best Health Care Mutual Funds for the Long Run

Vanguard Health Care Fund Investor

• Assets under management: $48.7 billion
• Dividend yield: 1.0%
• Expenses: 0.32%

Let's start with Vanguard Health Care Fund Investor (VGHCX (opens in new tab), $218.07), a straightforward but strong choice for investors wanting low expenses, low turnover and below-average risk compared to other health-care funds.

Vanguard Health Care takes a broad approach to health care, investing in various sectors both in the U.S. and abroad. Pharmaceutical stocks make up the biggest chunk of the portfolio at 40% of assets, but VGHCX investors are also exposed to biotech, health care equipment, health insurers and several other industries. Also, a good third of the portfolio is in international stocks.

This blend is well-evidenced in its top 10 holdings, which include the likes of America's UnitedHealth (UNH (opens in new tab)) and Pfizer (PFE (opens in new tab)), as well as the U.K.'s AstraZeneca (AZN (opens in new tab)) and Switzerland's Novartis (NVS (opens in new tab)).

One caveat for this health care fund is the buy-and-hold approach from Wellington Management, VGHCX's fund advisor. The approach tends to produce average returns compared to its peers. But it does so with a below-average risk profile, and remember: The category average still beats the S&P 500, which is a key goal when you're investing in sector funds.

Consider that VGHCX's 10-year average annual return of 14.9% is about 60 basis points lower than the category average (a basis point is one one-hundredth of a percent). But that's still better than the S&P 500's 13.6% average, and it has come with less volatility.

Learn more about VGHCX at the Vanguard provider site. (opens in new tab)

Fidelity Select Health Care Portfolio

• Assets under management: $9.2 billion
• Dividend yield: 0.3%
• Expenses: 0.70%

Fidelity Select Health Care Portfolio (FSPHX (opens in new tab), $32.09) is a slight shift from VGHCX, in that it dials up the risk but also produces better returns.

Fund manager Eddie Yoon has been at the helm of FSPHX since 2008; this tenure gives him complete credit for the outstanding 10-year annualized return of 19.2%. His is a three-part strategy that involves investing a heavy chunk of assets into steadily growing companies, then bolstering growth with biotechs as well as other fast-growing firms.

At the moment, this Kip 25 fund boasts 20%-plus allocations to health care equipment, biotechnology and pharmaceuticals, with another heavy slug (19%) in health insurance. The fund is filled out with life sciences, health-care tech and even software companies. You also get some international diversification at about 20% of assets. UnitedHealth, Switzerland's Roche Holding (RHHBY (opens in new tab)) and COVID play Regeneron (REGN (opens in new tab)) are all major players in this portfolio.

You'd think the aggressive stance would put Fidelity Select Health Care investors in considerable risk, but Morningstar says risk is about on par with the category average. That's a great tradeoff considering FSPHX's performance beats at least 80% of health care mutual funds in every significant time frame.

Note: PRHSX's status is "restricted." The fund is open to new investors, but you'll have to buy shares either directly from T. Rowe Price or through financial intermediaries with an existing position.

Learn more about FSPHX at the Fidelity provider site. (opens in new tab)

T. Rowe Price Health Sciences

• Assets under management: $15.5 billion
• Dividend yield: 0.1%
• Expenses: 0.76%

T. Rowe Price Health Sciences (PRHSX (opens in new tab), $94.41) has consistently outperformed its category peers in part because it's not afraid to overweight more aggressive areas of the health care sector.

PRHSX divides the health care sector into five main areas: pharmaceuticals, biotechnology, life sciences, services, and product and device providers. Allocation across these main areas will vary depending upon the potential that management sees with each respective area.

Health Sciences' management has its biggest chunk of assets (35%) dedicated to biotechs – the highest-risk, highest-reward segment of health care. The rest of the portfolio is split into 12%-20% chunks across the other four industries mentioned here. Top holdings are heavy in large caps: UnitedHealth, Intuitive Surgical (ISRG (opens in new tab)) and Vertex Pharmaceuticals (VRTX (opens in new tab)) represent some of the health care fund's biggest weights.

PRHSX is a well-above-average fund in most short-term time periods, but it has really shone in the long term. It beats 99% of its peers in the trailing 10- and 15-year periods, with 20.1% and 15.7% average annual returns, respectively.

Note that PRHSX is open to new investors but you'll have to buy shares either directly from T. Rowe Price or through financial intermediaries with an existing funded position.

Learn more about PRHSX at the T. Rowe Price provider site. (opens in new tab)

Janus Henderson Global Life Sciences T

• Assets under management: $4.4 billion
• Dividend yield: 0.63%
• Expenses: 0.92%

While Janus Henderson Global Life Sciences T (JAGLX (opens in new tab), $67.45) might sound like a fund focused specifically on one corner of the health care sector, it actually provides another means of broad access to several industries.

The JAGLX portfolio consists of companies that the fund management believes can address "unmet medical needs or improving efficiencies." In translation, shareholders of JAGLX get a healthy dose of pharmaceutical companies, biotech firms and medical device companies, including top holdings such as Merck (MRK (opens in new tab)), AbbVie (ABBV (opens in new tab)) – both Dividend Aristocrats – and Boston Scientific (BSX (opens in new tab)).

But biotech is the key to performance here, writes portfolio manager Andy Acker.

"We believe biotech's innovation will only accelerate from here, creating opportunities for investors who can identify the most promising drug developments," he says. "When we look at the Global Life Science Fund's cumulative 10-year return, we see that our positioning in biotechnology has been a key driver of outperformance."

This is a decidedly large-cap fund, with some 40% of the portfolio invested in companies larger than $100 billion. It's also heavily U.S. but with some (20%) international exposure.

From a performance standpoint, JAGLX offers the 1-2 punch that health care mutual fund investors are looking for, with an average risk profile but above-average returns in most time frames.

Learn more about JAGLX at the Janus Henderson provider site. (opens in new tab)

Fidelity Select Medical Technology and Devices Portfolio

• Assets under management: $7.3 billion
• Dividend yield: 0.0%
• Expenses: 0.71%

Fidelity Select Medical Technology and Devices Portfolio (FSMEX (opens in new tab), $69.52) isn't a sector fund, but instead an industry fund. In short, it focuses on companies dealing in medical equipment and devices (and related technologies), and doing so has helped it produce category-beating returns for some time.

Specifically, some 60% of the fund's assets is invested in health care equipment firms, while another 19% goes toward life sciences tools and services. The rest of the assets are sprinkled among insurers, health care tech, health care supplies and other industries. Top holdings include the likes of Thermo Fisher Scientific (TMO (opens in new tab)), Becton Dickinson (BDX (opens in new tab)) and Danaher (DHR (opens in new tab)).

This is a considerably more concentrated fund, at 47 holdings versus FSPHX's 88, but it still manages to tamp down risk, which Morningstar calls average.

From a performance standpoint, FSMEX has long been one of the best health care mutual funds you can buy. While Fidelity Select Medical Technology and Devices is better than a respectable 36% of its peers over the 52 weeks, at 32% returns, it's in the 90th percentile for all other longer-term time frames.

Learn more about FSMEX at the Fidelity provider site. (opens in new tab)