Large dogs run up the biggest upfront tab, but beware the high annual cost of rabbits and guinea pigs. By Jessica L. Anderson, Associate Editor September 10, 2012 1. Compare prices for flea-and-tick preventative and heartworm medications from the vet and from discount sites, such as www.1800petmeds.com.DOWNLOAD: The Kip Tips iPad App 2. Shop around for prescribed meds at pharmacies, big-box retailers and warehouse stores. Costco doesn’t require a membership to fill prescriptions, though you will pay a slightly higher price than members do. 3. Have a technician administer vaccines to save on office visits. 4. Contact your local shelter to ask about free or low-cost spaying and neutering services. 5. Buy food in bulk from a warehouse store. 6. Ask your pet store about manufacturer savings. Some offer frequent-buyer programs. 7. Check out daily-deal sites geared to pets, such as BarkingDeals.com and Coupaw.com, for toys, treats, supplies and more.